PittsburghV1, Main, Exploration, bibRecord, 001C43

Partial Volume Correction in Quantitative Amyloid Imaging

Identifieur interne : 001C43 ( Main/Exploration ); précédent : 001C42; suivant : 001C44

Partial Volume Correction in Quantitative Amyloid Imaging

Auteurs : Yi Su [États-Unis] ; Tyler M. Blazey [États-Unis] ; Abraham Z. Snyder [États-Unis] ; Marcus E. Raichle [États-Unis] ; Daniel S. Marcus [États-Unis] ; Beau M. Ances [États-Unis] ; Randall J. Bateman [États-Unis] ; Nigel J. Cairns [États-Unis] ; Patricia Aldea [États-Unis] ; Lisa Cash [États-Unis] ; Jon J. Christensen [États-Unis] ; Karl Friedrichsen [États-Unis] ; Russ C. Hornbeck [États-Unis] ; Angela M. Farrar [États-Unis] ; Christopher J. Owen [États-Unis] ; Richard Mayeux [États-Unis] ; Adam M. Brickman [États-Unis] ; William Klunk [États-Unis] ; Julie C. Price [États-Unis] ; Paul M. Thompson [États-Unis] ; Bernardino Ghetti [États-Unis] ; Andrew J. Saykin [États-Unis] ; Reisa A. Sperling [États-Unis] ; Keith A. Johnson [États-Unis] ; Peter R. Schofield [Australie] ; Virginia Buckles [États-Unis] ; John C. Morris [États-Unis] ; Tammie. Ls. Benzinger [États-Unis]

Source :

NeuroImage [ 1053-8119 ] ; 2014.

RBID : PMC:4300252

Descripteurs français

KwdFr :
- Algorithmes, Amyloïde (métabolisme), Benzothiazoles, Cortex cérébral (anatomopathologie), Cortex cérébral (imagerie diagnostique), Humains, Individualité, Maladie d'Alzheimer (imagerie diagnostique), Neuropathies amyloïdes (imagerie diagnostique), Radiopharmaceutiques, Reproductibilité des résultats, Simulation numérique, Tomographie par émission de positons, Études de cohortes, Études longitudinales, Études transversales.
MESH :
- anatomopathologie : Cortex cérébral.
- imagerie diagnostique : Cortex cérébral, Maladie d'Alzheimer, Neuropathies amyloïdes.
- métabolisme : Amyloïde.
- Algorithmes, Benzothiazoles, Humains, Individualité, Radiopharmaceutiques, Reproductibilité des résultats, Simulation numérique, Tomographie par émission de positons, Études de cohortes, Études longitudinales, Études transversales.

English descriptors

KwdEn :
- Algorithms, Alzheimer Disease (diagnostic imaging), Amyloid (metabolism), Amyloid Neuropathies (diagnostic imaging), Benzothiazoles, Cerebral Cortex (diagnostic imaging), Cerebral Cortex (pathology), Cohort Studies, Computer Simulation, Cross-Sectional Studies, Humans, Individuality, Longitudinal Studies, Positron-Emission Tomography, Radiopharmaceuticals, Reproducibility of Results.
MESH :
- chemical , metabolism : Amyloid.
- diagnostic imaging : Alzheimer Disease, Amyloid Neuropathies, Cerebral Cortex.
- pathology : Cerebral Cortex.
- Algorithms, Benzothiazoles, Cohort Studies, Computer Simulation, Cross-Sectional Studies, Humans, Individuality, Longitudinal Studies, Positron-Emission Tomography, Radiopharmaceuticals, Reproducibility of Results.

Abstract

Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders. As positron emission tomography (PET) scanners have limited spatial resolution, measured signals are distorted by partial volume effects. Various techniques have been proposed for correcting partial volume effects, but there is no consensus as to whether these techniques are necessary in amyloid imaging, and, if so, how they should be implemented. We evaluated a two-component partial volume correction technique and a regional spread function technique using both simulated and human Pittsburgh compound B (PiB) PET imaging data. Both correction techniques compensated for partial volume effects and yielded improved detection of subtle changes in PiB retention. However, the regional spread function technique was more accurate in application to simulated data. Because PiB retention estimates depend on the correction technique, standardization is necessary to compare results across groups. Partial volume correction has sometimes been avoided because it increases the sensitivity to inaccuracy in image registration and segmentation. However, our results indicate that appropriate PVC may enhance our ability to detect changes in amyloid deposition.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4300252

DOI: 10.1016/j.neuroimage.2014.11.058
PubMed: 25485714
PubMed Central: 4300252

Affiliations:

Le document en format XML

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<author><name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Columbia University Medical Center, New York, NY 10032</wicri:regionArea>
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<author><name sortKey="Klunk, William" sort="Klunk, William" uniqKey="Klunk W" first="William" last="Klunk">William Klunk</name>
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<wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213</wicri:regionArea>
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<author><name sortKey="Price, Julie C" sort="Price, Julie C" uniqKey="Price J" first="Julie C." last="Price">Julie C. Price</name>
<affiliation wicri:level="2"><nlm:aff id="A6">Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA</nlm:aff>
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<wicri:regionArea>Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213</wicri:regionArea>
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<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
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<author><name sortKey="Ghetti, Bernardino" sort="Ghetti, Bernardino" uniqKey="Ghetti B" first="Bernardino" last="Ghetti">Bernardino Ghetti</name>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
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<author><name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name>
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<wicri:regionArea>Center for Neuroimaging, Department of Radiology and Imaging Science, Indiana University School of Medicine, Indianapolis, IN 46202</wicri:regionArea>
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<author><name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
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<author><name sortKey="Johnson, Keith A" sort="Johnson, Keith A" uniqKey="Johnson K" first="Keith A." last="Johnson">Keith A. Johnson</name>
<affiliation wicri:level="2"><nlm:aff id="A11">Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
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<author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name>
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<country xml:lang="fr">Australie</country>
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<wicri:noRegion>NSW 2031</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A13">School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
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<author><name sortKey="Buckles, Virginia" sort="Buckles, Virginia" uniqKey="Buckles V" first="Virginia" last="Buckles">Virginia Buckles</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
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<author><name sortKey="Morris, John C" sort="Morris, John C" uniqKey="Morris J" first="John C." last="Morris">John C. Morris</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
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<author><name sortKey="Benzinger, Tammie Ls" sort="Benzinger, Tammie Ls" uniqKey="Benzinger T" first="Tammie. Ls." last="Benzinger">Tammie. Ls. Benzinger</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
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<idno type="pmid">25485714</idno>
<idno type="pmc">4300252</idno>
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<idno type="doi">10.1016/j.neuroimage.2014.11.058</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Partial Volume Correction in Quantitative Amyloid Imaging</title>
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</affiliation>
</author>
<author><name sortKey="Blazey, Tyler M" sort="Blazey, Tyler M" uniqKey="Blazey T" first="Tyler M." last="Blazey">Tyler M. Blazey</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Snyder, Abraham Z" sort="Snyder, Abraham Z" uniqKey="Snyder A" first="Abraham Z." last="Snyder">Abraham Z. Snyder</name>
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<country xml:lang="fr">États-Unis</country>
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</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Raichle, Marcus E" sort="Raichle, Marcus E" uniqKey="Raichle M" first="Marcus E." last="Raichle">Marcus E. Raichle</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Marcus, Daniel S" sort="Marcus, Daniel S" uniqKey="Marcus D" first="Daniel S." last="Marcus">Daniel S. Marcus</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Ances, Beau M" sort="Ances, Beau M" uniqKey="Ances B" first="Beau M." last="Ances">Beau M. Ances</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
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</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Bateman, Randall J" sort="Bateman, Randall J" uniqKey="Bateman R" first="Randall J." last="Bateman">Randall J. Bateman</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Cairns, Nigel J" sort="Cairns, Nigel J" uniqKey="Cairns N" first="Nigel J." last="Cairns">Nigel J. Cairns</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Aldea, Patricia" sort="Aldea, Patricia" uniqKey="Aldea P" first="Patricia" last="Aldea">Patricia Aldea</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Cash, Lisa" sort="Cash, Lisa" uniqKey="Cash L" first="Lisa" last="Cash">Lisa Cash</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
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<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Christensen, Jon J" sort="Christensen, Jon J" uniqKey="Christensen J" first="Jon J." last="Christensen">Jon J. Christensen</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Friedrichsen, Karl" sort="Friedrichsen, Karl" uniqKey="Friedrichsen K" first="Karl" last="Friedrichsen">Karl Friedrichsen</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
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<author><name sortKey="Hornbeck, Russ C" sort="Hornbeck, Russ C" uniqKey="Hornbeck R" first="Russ C." last="Hornbeck">Russ C. Hornbeck</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Farrar, Angela M" sort="Farrar, Angela M" uniqKey="Farrar A" first="Angela M." last="Farrar">Angela M. Farrar</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
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<author><name sortKey="Owen, Christopher J" sort="Owen, Christopher J" uniqKey="Owen C" first="Christopher J." last="Owen">Christopher J. Owen</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
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<wicri:regionArea>Department of Neurology, Columbia University Medical Center, New York, NY 10032</wicri:regionArea>
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</placeName>
</affiliation>
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<author><name sortKey="Klunk, William" sort="Klunk, William" uniqKey="Klunk W" first="William" last="Klunk">William Klunk</name>
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</affiliation>
</author>
<author><name sortKey="Price, Julie C" sort="Price, Julie C" uniqKey="Price J" first="Julie C." last="Price">Julie C. Price</name>
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<wicri:regionArea>Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213</wicri:regionArea>
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</affiliation>
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<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
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</placeName>
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</affiliation>
</author>
<author><name sortKey="Ghetti, Bernardino" sort="Ghetti, Bernardino" uniqKey="Ghetti B" first="Bernardino" last="Ghetti">Bernardino Ghetti</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name>
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</affiliation>
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<author><name sortKey="Johnson, Keith A" sort="Johnson, Keith A" uniqKey="Johnson K" first="Keith A." last="Johnson">Keith A. Johnson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A13">School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia</nlm:aff>
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<wicri:regionArea>School of Medical Sciences, University of New South Wales, Sydney, NSW 2052</wicri:regionArea>
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</author>
<author><name sortKey="Buckles, Virginia" sort="Buckles, Virginia" uniqKey="Buckles V" first="Virginia" last="Buckles">Virginia Buckles</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Morris, John C" sort="Morris, John C" uniqKey="Morris J" first="John C." last="Morris">John C. Morris</name>
<affiliation wicri:level="4"><nlm:aff id="A2">Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
<region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Benzinger, Tammie Ls" sort="Benzinger, Tammie Ls" uniqKey="Benzinger T" first="Tammie. Ls." last="Benzinger">Tammie. Ls. Benzinger</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Washington University School of Medicine, Saint Louis, MO, 63110</wicri:regionArea>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
<placeName><settlement type="city">Saint-Louis (Missouri)</settlement>
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<series><title level="j">NeuroImage</title>
<idno type="ISSN">1053-8119</idno>
<idno type="eISSN">1095-9572</idno>
<imprint><date when="2014">2014</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term>
<term>Alzheimer Disease (diagnostic imaging)</term>
<term>Amyloid (metabolism)</term>
<term>Amyloid Neuropathies (diagnostic imaging)</term>
<term>Benzothiazoles</term>
<term>Cerebral Cortex (diagnostic imaging)</term>
<term>Cerebral Cortex (pathology)</term>
<term>Cohort Studies</term>
<term>Computer Simulation</term>
<term>Cross-Sectional Studies</term>
<term>Humans</term>
<term>Individuality</term>
<term>Longitudinal Studies</term>
<term>Positron-Emission Tomography</term>
<term>Radiopharmaceuticals</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Algorithmes</term>
<term>Amyloïde (métabolisme)</term>
<term>Benzothiazoles</term>
<term>Cortex cérébral (anatomopathologie)</term>
<term>Cortex cérébral (imagerie diagnostique)</term>
<term>Humains</term>
<term>Individualité</term>
<term>Maladie d'Alzheimer (imagerie diagnostique)</term>
<term>Neuropathies amyloïdes (imagerie diagnostique)</term>
<term>Radiopharmaceutiques</term>
<term>Reproductibilité des résultats</term>
<term>Simulation numérique</term>
<term>Tomographie par émission de positons</term>
<term>Études de cohortes</term>
<term>Études longitudinales</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Amyloid</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cortex cérébral</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Alzheimer Disease</term>
<term>Amyloid Neuropathies</term>
<term>Cerebral Cortex</term>
</keywords>
<keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Cortex cérébral</term>
<term>Maladie d'Alzheimer</term>
<term>Neuropathies amyloïdes</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Amyloïde</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Cortex</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Algorithms</term>
<term>Benzothiazoles</term>
<term>Cohort Studies</term>
<term>Computer Simulation</term>
<term>Cross-Sectional Studies</term>
<term>Humans</term>
<term>Individuality</term>
<term>Longitudinal Studies</term>
<term>Positron-Emission Tomography</term>
<term>Radiopharmaceuticals</term>
<term>Reproducibility of Results</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Algorithmes</term>
<term>Benzothiazoles</term>
<term>Humains</term>
<term>Individualité</term>
<term>Radiopharmaceutiques</term>
<term>Reproductibilité des résultats</term>
<term>Simulation numérique</term>
<term>Tomographie par émission de positons</term>
<term>Études de cohortes</term>
<term>Études longitudinales</term>
<term>Études transversales</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Amyloid imaging is a valuable tool for research and diagnosis in dementing
disorders. As positron emission tomography (PET) scanners have limited spatial resolution,
measured signals are distorted by partial volume effects. Various techniques have been
proposed for correcting partial volume effects, but there is no consensus as to whether
these techniques are necessary in amyloid imaging, and, if so, how they should be
implemented. We evaluated a two-component partial volume correction technique and a
regional spread function technique using both simulated and human Pittsburgh compound B
(PiB) PET imaging data. Both correction techniques compensated for partial volume effects
and yielded improved detection of subtle changes in PiB retention. However, the regional
spread function technique was more accurate in application to simulated data. Because PiB
retention estimates depend on the correction technique, standardization is necessary to
compare results across groups. Partial volume correction has sometimes been avoided
because it increases the sensitivity to inaccuracy in image registration and segmentation.
However, our results indicate that appropriate PVC may enhance our ability to detect
changes in amyloid deposition.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Indiana</li>
<li>Massachusetts</li>
<li>Missouri (État)</li>
<li>Pennsylvanie</li>
<li>État de New York</li>
</region>
<settlement><li>Los Angeles</li>
<li>Saint-Louis (Missouri)</li>
</settlement>
<orgName><li>Université de Californie du Sud</li>
<li>École de médecine (Université Washington de Saint-Louis)</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Su, Yi" sort="Su, Yi" uniqKey="Su Y" first="Yi" last="Su">Yi Su</name>
</region>
<name sortKey="Aldea, Patricia" sort="Aldea, Patricia" uniqKey="Aldea P" first="Patricia" last="Aldea">Patricia Aldea</name>
<name sortKey="Ances, Beau M" sort="Ances, Beau M" uniqKey="Ances B" first="Beau M." last="Ances">Beau M. Ances</name>
<name sortKey="Ances, Beau M" sort="Ances, Beau M" uniqKey="Ances B" first="Beau M." last="Ances">Beau M. Ances</name>
<name sortKey="Bateman, Randall J" sort="Bateman, Randall J" uniqKey="Bateman R" first="Randall J." last="Bateman">Randall J. Bateman</name>
<name sortKey="Benzinger, Tammie Ls" sort="Benzinger, Tammie Ls" uniqKey="Benzinger T" first="Tammie. Ls." last="Benzinger">Tammie. Ls. Benzinger</name>
<name sortKey="Blazey, Tyler M" sort="Blazey, Tyler M" uniqKey="Blazey T" first="Tyler M." last="Blazey">Tyler M. Blazey</name>
<name sortKey="Brickman, Adam M" sort="Brickman, Adam M" uniqKey="Brickman A" first="Adam M." last="Brickman">Adam M. Brickman</name>
<name sortKey="Buckles, Virginia" sort="Buckles, Virginia" uniqKey="Buckles V" first="Virginia" last="Buckles">Virginia Buckles</name>
<name sortKey="Cairns, Nigel J" sort="Cairns, Nigel J" uniqKey="Cairns N" first="Nigel J." last="Cairns">Nigel J. Cairns</name>
<name sortKey="Cash, Lisa" sort="Cash, Lisa" uniqKey="Cash L" first="Lisa" last="Cash">Lisa Cash</name>
<name sortKey="Christensen, Jon J" sort="Christensen, Jon J" uniqKey="Christensen J" first="Jon J." last="Christensen">Jon J. Christensen</name>
<name sortKey="Farrar, Angela M" sort="Farrar, Angela M" uniqKey="Farrar A" first="Angela M." last="Farrar">Angela M. Farrar</name>
<name sortKey="Friedrichsen, Karl" sort="Friedrichsen, Karl" uniqKey="Friedrichsen K" first="Karl" last="Friedrichsen">Karl Friedrichsen</name>
<name sortKey="Ghetti, Bernardino" sort="Ghetti, Bernardino" uniqKey="Ghetti B" first="Bernardino" last="Ghetti">Bernardino Ghetti</name>
<name sortKey="Hornbeck, Russ C" sort="Hornbeck, Russ C" uniqKey="Hornbeck R" first="Russ C." last="Hornbeck">Russ C. Hornbeck</name>
<name sortKey="Johnson, Keith A" sort="Johnson, Keith A" uniqKey="Johnson K" first="Keith A." last="Johnson">Keith A. Johnson</name>
<name sortKey="Klunk, William" sort="Klunk, William" uniqKey="Klunk W" first="William" last="Klunk">William Klunk</name>
<name sortKey="Marcus, Daniel S" sort="Marcus, Daniel S" uniqKey="Marcus D" first="Daniel S." last="Marcus">Daniel S. Marcus</name>
<name sortKey="Mayeux, Richard" sort="Mayeux, Richard" uniqKey="Mayeux R" first="Richard" last="Mayeux">Richard Mayeux</name>
<name sortKey="Morris, John C" sort="Morris, John C" uniqKey="Morris J" first="John C." last="Morris">John C. Morris</name>
<name sortKey="Owen, Christopher J" sort="Owen, Christopher J" uniqKey="Owen C" first="Christopher J." last="Owen">Christopher J. Owen</name>
<name sortKey="Price, Julie C" sort="Price, Julie C" uniqKey="Price J" first="Julie C." last="Price">Julie C. Price</name>
<name sortKey="Raichle, Marcus E" sort="Raichle, Marcus E" uniqKey="Raichle M" first="Marcus E." last="Raichle">Marcus E. Raichle</name>
<name sortKey="Saykin, Andrew J" sort="Saykin, Andrew J" uniqKey="Saykin A" first="Andrew J." last="Saykin">Andrew J. Saykin</name>
<name sortKey="Snyder, Abraham Z" sort="Snyder, Abraham Z" uniqKey="Snyder A" first="Abraham Z." last="Snyder">Abraham Z. Snyder</name>
<name sortKey="Snyder, Abraham Z" sort="Snyder, Abraham Z" uniqKey="Snyder A" first="Abraham Z." last="Snyder">Abraham Z. Snyder</name>
<name sortKey="Sperling, Reisa A" sort="Sperling, Reisa A" uniqKey="Sperling R" first="Reisa A." last="Sperling">Reisa A. Sperling</name>
<name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
</country>
<country name="Australie"><noRegion><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name>
</noRegion>
<name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R." last="Schofield">Peter R. Schofield</name>
</country>
</tree>
</affiliations>
</record>

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Partial Volume Correction in Quantitative Amyloid Imaging

Partial Volume Correction in Quantitative Amyloid Imaging

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